I find that Buddhist psychology in some of its regional dialects (historically, through Tibet into China and Japan) approximates to a profound observation on the ultimate insubstantiality of this contingent, transient concept of Self that inhabits and invariably haunts us all.
In regards to AGI, I think a significant barrier is that the subjective experience and responsible agency we assert through language (and various technical ontologies) as being the kernel core of intelligence is actually a property of the language with which we define it more than of the thing it gestures towards.